Information Theory Perspective on Network Robustness

A crucial challenge in network theory is the study of the robustness of a network after facing a sequence of failures. In this work, we propose a dynamical definition of network's robustness based on Information Theory, that considers measurements of the structural changes caused by failures of the network's components. Failures are defined here, as a temporal process defined in a sequence. The robustness of the network is then evaluated by measuring dissimilarities between topologies after each time step of the sequence, providing a dynamical information about the topological damage. We thoroughly analyze the efficiency of the method in capturing small perturbations by considering both, the degree and distance distributions. We found the network's distance distribution more consistent in capturing network structural deviations, as better reflects the consequences of the failures. Theoretical examples and real networks are used to study the performance of this methodology.Comment: 5 pages, 2 figures, submitte

Diffusion capacity of single and interconnected networks

Understanding diffusive processes in networks is a significant challenge in complexity science. Networks possess a diffusive potential that depends on their topological configuration, but diffusion also relies on the process and initial conditions. This article presents Diffusion Capacity, a concept that measures a node’s potential to diffuse information based on a distance distribution that considers both geodesic and weighted shortest paths and dynamical features of the diffusion process. Diffusion Capacity thoroughly describes the role of individual nodes during a diffusion process and can identify structural modifications that may improve diffusion mechanisms. The article defines Diffusion Capacity for interconnected networks and introduces Relative Gain, which compares the performance of a node in a single structure versus an interconnected one. The method applies to a global climate network constructed from surface air temperature data, revealing a significant change in diffusion capacity around the year 2000, suggesting a loss of the planet’s diffusion capacity that could contribute to the emergence of more frequent climatic events.Research partially supported by Brazilian agencies FAPEMIG, CAPES, and CNPq. P.M.P. acknowledges support from the “Paul and Heidi Brown Preeminent Professorship in ISE, University of Florida”, and RSF 14-41- 00039, Humboldt Research Award (Germany) and LATNA, Higher School of Economics, RF. C.M. acknowledges partial support from Spanish MINECO (PID2021-123994NB-C21) and ICREA ACADEMIA. A.D.- G. knowledges support from the Spanish grants PGC2018-094754-BC22 and PID2021-128005NB-C22, funded by MCIN/AEI/ 10.13039/ 501100011033 and “ERDF A way of making Europe”; and from Generalitat de Catalunya (2021SGR00856). M.G.R acknowledges partial support from FUNDEP.Peer ReviewedPostprint (published version

The integrated uncapacitated lot sizing and bin packing problem

In the integrated uncapacitated lot sizing and bin packing problem, we have to couple lot sizing decisions of replenishment from single product suppliers with bin packing decisions in the delivery of client orders. A client order is composed of quantities of each product, and the quantities of such an order must be delivered all together no later than a given period. The quantities of an order must all be packed in the same bin, and may be delivered in advance if it is advantageous in terms of costs. We assume a large enough set of homogeneous bins available at each period. The costs involved are setup and inventory holding costs and the cost to use a bin as well. All costs are variable in the planning horizon, and the objective is to minimize the total cost incurred. We propose mixed integer linear programming formulations and a combinatorial relaxation where it is no longer necessary to keep track of the specific bin where each order is packed. An aggregate delivering capacity is computed instead. We also propose heuristics using different strategies to couple the lot sizing and the bin packing subproblems. Computational experiments on instances with different configurations showed that the proposed methods are efficient ways to obtain small optimality gaps in reduced computational times

The Lagrangean relaxation for the flow shop scheduling problem with precedence constraints, release dates and delivery times

This work aims to present a methodology to support a company in the automotive business on scheduling the jobs on its final processes. These processes are: (i) checking the final product and (ii) loading the dispatch trucks. These activities are usually found in the outbound area of any manufacturing company. The problem faced is defined as the flow shop problem with precedence constraints, release dates, and delivery times. The major objective is to minimize the latest date a client receives its products. We present a time-indexed integer mathematical model to compute feasible solutions for the presented problem. Moreover, we take advantage of the Lagrangean Relaxation procedure to compute valid lower and upper bounds. The experiments were held based on the company’s premises. As a conclusion, the results showed that the methodology proposed was able to compute feasible solutions for all the instances tested. Also, the Lagrangean Relaxation approach was able to calculate better bounds in a shorter computational time than the Mathematical problem for the more complicated instances.This work has been partially supported by Doctorats Industrials, Agéncia de Gestió d’Ajuts Universitaria I de Recerca, Generalitat de Catalunya [2016 DI 022] (Marcelus Fabri), the Spanish Ministry of Economy and Competitiveness [TRA2013-48180-C3-2-P] (Helena Ramalhinho), and CAPES, CNPq, and FAPEMIG, Brazil (Martín Gómez Ravetti, Mauricio C. de Souza)

Quantification of network structural dissimilarities

© 2017. This version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/Identifying and quantifying dissimilarities among graphs is a fundamental and challenging problem of practical importance in many fields of science. Current methods of network comparison are limited to extract only partial information or are computationally very demanding. Here we propose an efficient and precise measure for network comparison, which is based on quantifying differences among distance probability distributions extracted from the networks. Extensive experiments on synthetic and real-world networks show that this measure returns non-zero values only when the graphs are non-isomorphic. Most importantly, the measure proposed here can identify and quantify structural topological differences that have a practical impact on the information flow through the network, such as the presence or absence of critical links that connect or disconnect connected components.Peer Reviewe

Development of immunotherapy targeting melanoma stem cells

Diversity, understood as the variety of different elements or configurations that an extensive system has, is a crucial property that allows maintaining the system’s functionality in a changing environment, where failures, random events or malicious attacks are often unavoidable. Despite the relevance of preserving diversity in the context of ecology, biology, transport, finances, etc., the elements or configurations that more contribute to the diversity are often unknown, and thus, they can not be protected against failures or environmental crises. This is due to the fact that there is no generic framework that allows identifying which elements or configurations have crucial roles in preserving the diversity of the system. Existing methods treat the level of heterogeneity of a system as a measure of its diversity, being unsuitable when systems are composed of a large number of elements with different attributes and types of interactions. Besides, with limited resources, one needs to find the best preservation policy, i.e., one needs to solve an optimization problem. Here we aim to bridge this gap by developing a metric between labeled graphs to compute the diversity of the system, which allows identifying the most relevant components, based on their contribution to a global diversity value. The proposed framework is suitable for large multiplex structures, which are constituted by a set of elements represented as nodes, which have different types of interactions, represented as layers. The proposed method allows us to find, in a genetic network (HIV-1), the elements with the highest diversity values, while in a European airline network, we systematically identify the companies that maximize (and those that less compromise) the variety of options for routes connecting different airports.Peer ReviewedPostprint (published version